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The tumor suppressor p53 plays a critical role in maintaining cellular homeostasis under genotoxic stress. Recent evidence suggests that post-translational modifications of p53, particularly phosphorylation at Ser15, are essential for its transcriptional activation [1].
In this study, we demonstrate that our novel compound X-47 significantly enhances p53-Ser15 phosphorylation in triple-negative breast cancer cell lines, resulting in a 3.2-fold increase in apoptosis rates compared to vehicle-treated controls (p < 0.001) [Fig. 3].
| Original Text | Polished Text | Reason |
|---|---|---|
| "We did some tests and found that the drug worked pretty well on cancer cells." | "Compound X-47 demonstrated potent anti-proliferative activity against triple-negative breast cancer cell lines, with an IC50 of 2.3 uM." | Replaced colloquial language with quantitative, discipline-specific terminology and precise metrics. |
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